I interpret the word ANSWER to correspond to the numbers 123456, so A=1, N=2, ... In particular, A=1, S=3 and E=5. These letters appear in SEAD, so we appear to have 351d and the number 123456, perhaps as an equation. It so happens that 123456=351^2+255 (351^2=123201.) What is the significance of the upper and lower case, italic, strike through and underscore?
The word WORLD has two letters in common with ANSWER, where W=4 and R=6, so we have WORLD as 4O6LD partially transcribed. The only letter of ANSWER not so far used is N(=2). The identity 123456=351^2+255 could be converted to ANSWER=SEA^N+NEE.
If we write down the struck through letters we have OR SWER, lowercase: OD ASE, uppercase: WR NWR, italic: AER, underscore: D WER. Could these signify equations? No, because the italic is a number on its own and WR NWR has two letters in common on both "sides". So it would appear we can't attach significance to the case or presentation of the letters.
The letters SEAD are part of the arithmetic priority acronym PEMDAS, where S=subtract, E=exponent, A=add, D=divide. Each operator requires two operands. It would appear that, under this interpretation, we would apply the operators to 5 operands thus: a-b^c+d/e. But we don't know what the letters a, b c, d, e are, and the only given number is 123456 having 6 digits rather than 5.
So far then all we have is coincidences.