x2+4xy+16y2 has only complex factors. To find them:
x2+4xy+16y2=0,
x2+4xy=-16y2, add 4y2 to bothe sides to complete the square on the LHS:
x2+4xy+4y2=4y2-16y2=-12y2,
(x+2y)2=-12y2,
(x+2y)2+12y2=0,
(x+2y+2iy√3)(x+2y-2iy√3)=0, so x=-2y±2iy√3=2y(-1±i√3).